Imipenem antagonism of the in vitro activity of piperacillin against Pseudomonas aeruginosa.

نویسندگان

  • M A Bertram
  • L S Young
چکیده

The MICs of imipenem and piperacillin, alone and in combination, against Pseudomonas aeruginosa were determined in a checkerboard titration microdilution assay. A dramatic, one-way antagonism of imipenem for piperacillin was demonstrated in 28 of the 35 strains examined; antagonism was associated with the induction of a beta-lactamase.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 26 2  شماره 

صفحات  -

تاریخ انتشار 1984